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Alias:Xolegel; Extina; (+)-Ketoconazole; Nizoral
CAS NO.:65277-42-1
EINECS No.:265-667-4
Molecular Formula:C26H28Cl2N4O4
Molecular Weight:531.43
Purity:99%
Appearance:White Crystalline Powder
Grade:Pharmaceutical Grade
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Ketoconazole is a synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.
Ketoconazole is an imidazole fungicidal agent with a very broad spectrum of activity against many fungal species that is used for treatment of superficial and systemic fungal infections. Ketoconazole is a well documented cause of clinically apparent acute drug induced liver injury and is no longer recommended as a first line antifungal agent.
