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Isotretinoin CAS 4759-48-2

Isotretinoin CAS 4759-48-2
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FOB Price: Negotiable 
Port: shenzhen 
Minimum Order Quantity: 0.01 kg 
Supply Ability: 3000 kg
Place Of Origin: China
Delivery Time: 3 days
Expiry Date: long-term effectiveness
Last Update: 2018-04-16
Views: 17
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Product Details
Alias: 13-cis-ra;13-cis-retinoicaci;13-ra;accutane;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780 
CAS: 4759-48-2 
M.F.: C20H28O2 
M.W.: 300.44 
EINECS: 225-296-0 
M.P.  172-175 °C(lit.) 
Related Categories: Dermatosis Skin Cosmetology;Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;Antineoplastics;Medicine and Biochemistry;Dermatology;Other Drugs;Drugs;API
Storage conditions -20°C
Property: Obtain orange-red flaky crystals from isopropanol, melting point 174-175°C. UV absorption maximum: 354 nm (ε39800). Acute toxicity LD50 (20 days) mice, rats (mg/kg): 904, 901 intraperitoneal injection; 3389> 4000 oral.
Usage 1. As a vitamin A drug, it has the function of inhibiting the proliferation and differentiation of skin gland cells strongly and quickly. It is highly effective for severe cystic acne. This product is better in gastrointestinal absorption, but the local drug is not effective. Hemorrhoids, cystic acne, and acne vulgaris, which are not effective for other medications, have a certain effect on skin disorders such as rosacea, ichthyosis, hair follicle keratoses, and hair red herpes.
Usage 2. For severe acne and so on.
Usage 3. Anti-skin keratolytic drugs.
Usage 4. For the treatment of severe acne embolism
Production methods: After the reaction of β-ionone and ethylmagnesium chloride, triphenylphosphonium is reacted with triphenylphosphine to form a triphenylsulfonium salt, which is then reacted with a cyclopentenone derivative to generate isotretinoin and its 8Z isomer. After separation of the 8Z isomer, it is isomerized to isotretinoin by the action of palladium nitrate. PI
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