Troxerutin

Characteristics

-Appearance

-Solubility

Yellowish-green crystalline powder,

hydroscopic.

Freely soluble in water, slightly

soluble in ethanol; practically

insoluble in methylene chloride

Identification

A. IR

B. Examine the chromatogram

Identical with that of the reference

(comparison:troxerutin CRS)

Obtained in the test for composition

Tests

-principal peak

Trihydroxyethylrutin

≥80%

-any other peak

Monohydroxyethylrutin

Dihydroxyethylrutin

Tetrahydroxyethylrutin

For each peak,maximum 5%, except 
for 1 peak which can be  maximum 10%

-Loss on drying          

≤5.0%

-Sulphated ashes

≤0.4%

Heavy metals

≤20ppm

Ethylene oxide (GC)

≤1ppm

Assay(UV, Accoding to dried substance)

95.0%-105.0%

Microbiological test

-Total plate count

-Yeast & mould

-E.Coli

Pseudomonas aeruginosa

≤1000cuf/g

≤100cfu/g

Absent

Absent