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African Griffonia Seed Extract 5-HTP
CAS 56-69-9 5-HTP
L-5-Hydroxytryptophan
5-Hydroxytryptophan
Griffonia simplicifolia extract
Griffonia seed extract
Griffonia simplicifolia extract
Griffonia seed extract
EINECS 200-284-8
L-5-hydroxytryptophan (5-HTP) is a chemical that the body makes from tryptophan (an essential amino acid, which has to be obtained through food). After tryptophan is converted into 5-HTP, the chemical is then converted into another chemical called serotonin (a neurotransmitter, which relays signals between brain cells). L-5-hydroxytryptophan dietary supplements help raise serotonin levels in the brain. Since serotonin helps regulate mood and behavior, L-5-hydroxytryptophan may have a positive effect on sleep, mood, anxiety, appetite, and pain sensation.
L-5-hydroxytryptophan is not present in the foods we eat, although tryptophan is. (Eating foods with tryptophan does not increase L-5-hydroxytryptophan levels very much, however.) As a supplement, L-5-hydroxytryptophan is obtained from the seeds of an African plant calledGriffonia simplicifolia.
L-5-hydroxytryptophan may help treat a wide variety of conditions related to low serotonin levels, including the following, but the evidence is limited for all of these uses:
Depression
Some small studies indicate that L-5-hydroxytryptophan may be as effective as certain antidepressant drugs in treating individuals with mild-to-moderate depression. L-5-hydroxytryptophan increases the levels of serotonin in the brain. One study compared the effects of L-5-hydroxytryptophan to fluvoxamine (Luvox) in 63 people and found that those who were given L-5-hydroxytryptophan did just as well as those who received the SSRI. In addition, those who took L-5-hydroxytryptophan had fewer side effects than those who took Luvox. However, these studies were too small to say for sure if L-5-hydroxytryptophan works. More and larger studies are needed.
Fibromyalgia
Three studies have suggested that L-5-hydroxytryptophan can improve symptoms of fibromyalgia, including pain, anxiety, morning stiffness, and fatigue. Many people with fibromyalgia have low levels of serotonin, and antidepressants are commonly prescribed. Since L-5-hydroxytryptophan, like antidepressants, raises levels of serotonin in the brain, it may be effective as well. However, it does not work for all people with fibromyalgia, and more studies are needed to understand its effect.
Insomnia
In one study, people who took L-5-hydroxytryptophan went to sleep quicker and experienced a deeper sleep than those who took placebo. Researchers recommend 200 - 400 mg at night to stimulate serotonin, but it may take 6 - 12 weeks to be fully effective.
Migraines and Headaches
Some studies suggest that high doses of L-5-hydroxytryptophan may be effective in children and adults with various types of headaches, including migraines. However, the evidence is mixed, with other studies showing no effect.
Obesity
Hot Flashes
In small studies L-5-hydroxytryptophan increases serotonin levels, reducing depressive symptoms and decreasing hot flashes in a manner similar to SSRIs, but without the risk of breast cell stimulation.
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PRODUCT NAME
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L-5-Hydroxytryptophan
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BATCH NO
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090925
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BATCH SIZE
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200 KGS
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MANU DATE
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2009,09,25
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SHELF LIFE
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2 years
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ANALYSIS
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SPECIFICATION
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RESULTS
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TEST METHODS
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Appearance
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White to gray white fine powder
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Complies
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Visual
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Odor
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Characteristic
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Complies
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Organoleptic
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Specific Optical Rotation
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-30.9°~-34.7°
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-32.5°
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CP2000
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Solubility
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Slightly soluble in water
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Complies
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/
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Loss on Drying
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≤10.0%
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6.52%
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105°C/3hrs
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Residue on Ignition
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≤0.5%
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0.42%
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750°C/5hrs
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Extract Solvent
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Ethanol
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Complies
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/
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Heavy Metals
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<10ppm
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Complies
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CP2000
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As
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<2ppm
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Complies
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AAS
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Residual Solvents
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Eur.Pharm.2000
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Complies
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GC
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Total Plate Count
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<1000cfu/g
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Negative
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CP2000
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Yeast & Mold
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<100cfu/g
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Negative
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CP2000
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E.Coli
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Negative
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Complies
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CP2000
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Salmonella
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Negative
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Complies
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CP2000
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Assay( on anhydrous basis)
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L-5-HTP
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≥98.0%
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98.45%
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HPLC
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Funcitons
1. Anti-depressant and mood enhancer.
2. Regulates brain serotonin levels.
3. Appetite suppressant for weight loss.
4. Sleep aid for insomnia treatment.
5. Depression treatment.
6. Migraine Headaches and Fibromyalgia.
